New MaCCLAB paper published in Diabetes!
Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age.
Diabetes, 2022 May 1;71(5):1081-1098. doi: 10.2337/db21-0536
Marino et al. show how DM hampers CSC biology, inhibiting CSCs’ regenerative potential through the induction of cellular senescence and SASP independently from aging. Senolytics clear senescence, abrogating the SASP and restoring a fully proliferative/differentiation-competent hCSC pool in T2DM with normalization of cardiac function.